The study shows that cellular “hotspots” in the brain can indicate the earliest signs of cancer



ANI |
Updated:
April 15, 2021, 7:55 a.m. IS

London [UK], April 15 (ANI): A team of researchers has found small clusters of cells in the brain that identify locations where tumors could become malignant.
The study, conducted by the London Institute of Psychiatry, Psychology and Neuroscience at King’s College in collaboration with the NHS Foundation Trust at King’s College Hospital, was published in the journal Neuro-Oncology Advances.
The study, published in Neuro-Oncology Advances, analyzed living human brain tissue from 20 people who underwent brain tumor surgery at King’s College Hospital, Europe’s largest neuro-oncology center. The researchers found groups of tumor cells clustered around blood vessels and believe these sites could be the seedbed for malignant progression, the process by which a tumor turns into a rapidly growing and uncontrolled cancer.

To examine the brain tissue, neurosurgeons cooled the surface of the brain. Then they took a sample and placed it in a cerebrospinal fluid solution. After being transported to the laboratory, the tissue was placed in a miniaturized incubation chamber specially developed for this study, in which it was immersed in a solution that makes the living tumor cells fluoresce and can be more easily examined under a microscope.
Dr. Gerald Finnerty, Lead Author at King’s IoPPN and Honorary Consultant Neurologist at King’s College Hospital, said, “This research is of tremendous importance. The” hotspots “we found revealed many of the hallmarks of cancer. The ability to identify areas of high risk of malignancy Locating it gives us a much better chance of determining why the brain tumor is becoming cancerous. “
Brain tumors are difficult to treat because they are so invasive. Even after surgery and chemoradiotherapy, there is still a high risk of some cancer cells remaining, which increases the likelihood that cancer will return. Unfortunately, this means that many of the young adults affected do not survive longer than a year.
Dr. Alastair Kirby, lead author of the study, said, “It has been a privilege to work with brain cancer patients and our neurosurgical team to carry out this highly innovative research. Living human brain tissue offers great opportunities to study how a person’s brain tumor reacts to this Revolutionize therapy and bring precision medicine against brain tumors one step closer. “(ANI)

Source